Table 3.

ORs with 95% CIs for overall VTE and subgroups according to quartiles of VWF plasma levels

VTE subgroup	Controls (n = 843)	Cases	Model 1	Model 2	Model 3
Overall VTE		n = 414
VWF Q1	210	88	Ref.	Ref.	Ref.
VWF Q2	211	94	1.07 (0.75-1.51)	1.03 (0.72-1.46)	1.03 (0.72-1.48)
VWF Q3	210	105	1.20 (0.85-1.70)	1.20 (0.85-1.69)	1.20 (0.84-1.71)
VWF Q4	212	127	1.45 (1.03-2.03)	1.35 (0.96-1.90)	1.36 (0.96-1.92)
P value for trend			.02	.05	.05
Provoked VTE		n = 241
VWF Q1	210	62	Ref.	Ref.	Ref.
VWF Q2	211	56	0.89 (0.59-1.34)	0.86 (0.56-1.30)	0.87 (0.57-1.33)
VWF Q3	210	62	0.97 (0.65-1.46)	0.96 (0.64-1.45)	0.98 (0.65-1.49)
VWF Q4	212	61	0.94 (0.62-1.41)	0.88 (0.58-1.34)	0.90 (0.59-1.37)
P value for trend			.9	.7	.8
Unprovoked VTE		n = 173
VWF Q1	210	26	Ref.	Ref.	Ref.
VWF Q2	211	38	1.50 (0.88-2.57)	1.49 (0.86-2.57)	1.46 (0.84-2.52)
VWF Q3	210	43	1.75 (1.03-2.97)	1.78 (1.04-3.03)	1.72 (1.00-2.94)
VWF Q4	212	66	2.74 (1.66-4.54)	2.59 (1.55-4.32)	2.52 (1.51-4.22)
P value for trend			<.001	<.001	<.001

Model 1: adjusted for age and sex. Model 2: model 1 + BMI and CRP. Model 3: model 2 + smoking, hypertension, and estrogen use.

Q, quartile; Ref., reference.