Table 4.

ORs with 95% CIs for overall, provoked, and unprovoked DVT and PE, according to quartiles of plasma VWF level

VTE subgroup	Controls (n = 843)	Cases	Model 1	Model 2	Model 3
Overall DVT		n = 259
VWF Q1	210	53	Ref.	Ref.	Ref.
VWF Q2	211	57	1.08 (0.71-1.65)	1.07 (0.70-1.64)	1.06 (0.69-1.63)
VWF Q3	210	65	1.26 (0.83-1.90)	1.26 (0.83-1.90)	1.23 (0.81-1.87)
VWF Q4	212	84	1.63 (1.09-2.43)	1.52 (1.01-2.29)	1.49 (0.99-2.25)
P value for trend			0.01	0.03	0.04
Provoked DVT		n = 156
VWF Q1	210	45	Ref.	Ref.	Ref.
VWF Q2	211	36	0.79 (0.49-1.27)	0.78 (0.48-1.27)	0.78 (0.48-1.27)
VWF Q3	210	38	0.82 (0.51-1.33)	0.83 (0.51-1.33)	0.83 (0.51-1.34)
VWF Q4	212	37	0.78 (0-48-1.28)	0.74 (0.45-1.21)	0.74 (0.45-1.22)
P value for trend			.4	.3	.3
Unprovoked DVT		n = 103
VWF Q1	210	8	Ref.	Ref.	Ref.
VWF Q2	211	21	2.73 (1.18-6.33)	2.78 (1.19-6.47)	2.73 (1.17-6.40)
VWF Q3	210	27	3.74 (1.65-8.47)	3.79 (1.66-8.62)	3.59 (1.57-8.23)
VWF Q4	212	47	6.73 (3.07-14.76)	6.40 (2.90-14.12)	6.18 (2.78-13.70)
P value for trend			<.001	<.001	<.001
Overall PE		n = 155
VWF Q1	210	35	Ref.	Ref.	Ref.
VWF Q2	211	37	1.04 (0.63-1.72)	0.96 (0.58-1.61)	0.99 (0.59-1.67)
VWF Q3	210	40	1.12 (0.68-1.84)	1.10 (0.67-1.83)	1.15 (0.69-1.92)
VWF Q4	212	43	1.18 (0.72-1.93)	1.11 (0.67-1.84)	1.14 (0.69-1.91)
P value for trend			.5	.6	.5
Provoked PE		n = 85
VWF Q1	210	17	Ref.	Ref.	Ref.
VWF Q2	211	20	1.15 (0.59-2.27)	1.05 (0.53-2.10)	1.14 (0.56-2.31)
VWF Q3	210	24	1.36 (0.70-2.63)	1.32 (0.68-2.56)	1.43 (0.72-2.83)
VWF Q4	212	24	1.33 (0.69-2.57)	1.24 (0.63-2.42)	1.33 (0.67-2.64)
P value for trend			.4	.4	.3
Unprovoked PE		n = 70
VWF Q1	210	18	Ref.	Ref.	Ref.
VWF Q2	211	17	0.94 (0.47-1.88)	0.90 (0.44-1.83)	0.88 (0.43-1.80)
VWF Q3	210	16	0.89 (0.44-1.80)	0.89 (0.43-1.82)	0.89 (0.43-1.84)
VWF Q4	212	19	1.04 (0.52-2.08)	0.98 (0.49-1.98)	0.97 (0.48-1.96)
P value for trend			.9	.9	.9

Model 1: adjusted for age and sex. Model 2: model 1 + BMI and CRP. Model 3: model 2 + smoking, hypertension, and estrogen use.