Table 1.
Patient ID | Age, y | Disease/treatment | GATA2 | IFD | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Diagnosis | HCT | Proximal chemotherapy | Mutation | VAF | Somatic confidence | Category | Infection site | Mycology | ANC <0.5 × 103/μL | ||
G1 | 51 | AML | Yes | MEC | N317H | 0.12 | Definite | Proven | Brain | Pathology with invasive fungal forms, culture with Scedosporium sp. | Yes |
G2 | 68 | AML | No | MEC | R398W | 0.30 | Definite | Proven | Pulmonary, disseminated candidiasis | Elevated serum galactomannan, C tropicalis bloodstream infection | Yes |
G3 | 58 | MDS | Yes | — | R398W | 0.37 | Definite | Proven | Pulmonary, disseminated candidiasis | Elevated serum galactomannan, C albicans bloodstream infection | Yes |
G4 | 72 | AML | Yes | — | G320D | 0.37 | Likely | Proven | Disseminated candidiasis | C tropicalis bloodstream infection | Yes |
G5 | 51 | MDS/MPN | Yes | — | R396Q | 0.08 | Definite | Proven | Pulmonary | Pathology with invasive fungal forms, BAL culture with Rhizopus sp. | No |
G6 | 49 | AML | Yes | Decitabine | G320D | 0.44 | Definite | Probable | Sinus | Elevated serum galactomannan | Yes |
G7 | 70 | AML | Yes | Clofarabine, cytarabine | T301K | 0.31 | Definite | Probable | Pulmonary | Elevated serum β-d-glucan | Yes |
G8 | 35 | AML | Yes | Decitabine | L321P | 0.16 | Definite | Probable | Pulmonary | BAL culture with A fumigatus | Yes |
G9 | 53 | AML | Yes | MEC | A12fs* | 0.44 | Definite | Probable | Pulmonary | Elevated BAL galactomannan | Yes |
G10 | 68 | AML | No | CPX-351 | M388_K390del | 0.31 | Definite | Probable | Pulmonary | Elevated serum β-d-glucan | Yes |
G11 | 63 | AML | No | Decitabine/venetoclax | G320D | 0.41 | Likely | Probable | Pulmonary | Elevated serum galactomannan | Yes |
G12 | 61 | MDS | No | CPX-351 | G82fs* | 0.08 | Definite | Probable | Pulmonary | Elevated serum β-d-glucan | Yes |
G13 | 50 | AML | Yes | — | N297S | 0.45 | Likely | Probable | Pulmonary | Elevated serum galactomannan/β-d-glucan | Yes |
G14 | 68 | MDS/MPN | Yes | Decitabine | P385R | 0.13 | Definite | Probable | Pulmonary | BAL culture with A fumigatus | No |
G15 | 62 | AML | Yes | — | V16fs* | 0.38 | Definite | Probable | Pulmonary | Elevated serum β-d-glucan | Yes |
G16 | 54 | AML | No | αCD123 ADC | K282fs* | 0.21 | Definite | Possible-treated | Pulmonary | — | Yes |
G17 | 66 | AML | No | Daunorubicin, cytarabine | T354M, P121fs* | 0.44, 0.36 | Definite | Possible-treated | Pulmonary | — | Yes |
G18 | 66 | AML | No | Daunorubicin, cytarabine | D99fs* | 0.18 | Definite | Possible-treated | Pulmonary | — | Yes |
G19 | 70 | AML | No | MEC | M388_E391del | 0.44 | Definite | Possible-treated | Pulmonary | — | Yes |
G20 | 55 | AML | No | Daunorubicin, cytarabine | G274fs* | 0.13 | Definite | Possible-treated | Pulmonary | — | Yes |
G21 | 43 | MDS/MPN | Yes | — | L321F | 0.15 | Definite | Possible-treated | Pulmonary | — | Yes |
αCD123-ADC, αCD123-targeting antibody-drug conjugate; ANC, absolute neutrophil count; MEC, mitoxantrone, etoposide, and intermediate-dose Ara-C; VAF, variant allele frequency (VAF at initial index detection).