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. 2020 Dec 31;5(1):54–60. doi: 10.1182/bloodadvances.2020002854

Table 1.

Clinical, genetic, and IFD characteristics in the GATA2 Cohort

Patient ID Age, y Disease/treatment GATA2 IFD
Diagnosis HCT Proximal chemotherapy Mutation VAF Somatic confidence Category Infection site Mycology ANC <0.5 × 103/μL
G1 51 AML Yes MEC N317H 0.12 Definite Proven Brain Pathology with invasive fungal forms, culture with Scedosporium sp. Yes
G2 68 AML No MEC R398W 0.30 Definite Proven Pulmonary, disseminated candidiasis Elevated serum galactomannan, C tropicalis bloodstream infection Yes
G3 58 MDS Yes R398W 0.37 Definite Proven Pulmonary, disseminated candidiasis Elevated serum galactomannan, C albicans bloodstream infection Yes
G4 72 AML Yes G320D 0.37 Likely Proven Disseminated candidiasis C tropicalis bloodstream infection Yes
G5 51 MDS/MPN Yes R396Q 0.08 Definite Proven Pulmonary Pathology with invasive fungal forms, BAL culture with Rhizopus sp. No
G6 49 AML Yes Decitabine G320D 0.44 Definite Probable Sinus Elevated serum galactomannan Yes
G7 70 AML Yes Clofarabine, cytarabine T301K 0.31 Definite Probable Pulmonary Elevated serum β-d-glucan Yes
G8 35 AML Yes Decitabine L321P 0.16 Definite Probable Pulmonary BAL culture with A fumigatus Yes
G9 53 AML Yes MEC A12fs* 0.44 Definite Probable Pulmonary Elevated BAL galactomannan Yes
G10 68 AML No CPX-351 M388_K390del 0.31 Definite Probable Pulmonary Elevated serum β-d-glucan Yes
G11 63 AML No Decitabine/venetoclax G320D 0.41 Likely Probable Pulmonary Elevated serum galactomannan Yes
G12 61 MDS No CPX-351 G82fs* 0.08 Definite Probable Pulmonary Elevated serum β-d-glucan Yes
G13 50 AML Yes N297S 0.45 Likely Probable Pulmonary Elevated serum galactomannan/β-d-glucan Yes
G14 68 MDS/MPN Yes Decitabine P385R 0.13 Definite Probable Pulmonary BAL culture with A fumigatus No
G15 62 AML Yes V16fs* 0.38 Definite Probable Pulmonary Elevated serum β-d-glucan Yes
G16 54 AML No αCD123 ADC K282fs* 0.21 Definite Possible-treated Pulmonary Yes
G17 66 AML No Daunorubicin, cytarabine T354M, P121fs* 0.44, 0.36 Definite Possible-treated Pulmonary Yes
G18 66 AML No Daunorubicin, cytarabine D99fs* 0.18 Definite Possible-treated Pulmonary Yes
G19 70 AML No MEC M388_E391del 0.44 Definite Possible-treated Pulmonary Yes
G20 55 AML No Daunorubicin, cytarabine G274fs* 0.13 Definite Possible-treated Pulmonary Yes
G21 43 MDS/MPN Yes L321F 0.15 Definite Possible-treated Pulmonary Yes

αCD123-ADC, αCD123-targeting antibody-drug conjugate; ANC, absolute neutrophil count; MEC, mitoxantrone, etoposide, and intermediate-dose Ara-C; VAF, variant allele frequency (VAF at initial index detection).