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. 2021 Jan 13;11(1):e255. doi: 10.1002/ctm2.255

FIGURE 1.

FIGURE 1

The lncRNA H19 serves as a sponge for miR‐29b‐3p in chondrocytes. A, The subcellular localization of lncRNA H19 was verified by FISH analysis; scale bar: 200 μm. B, The binding sequences of lncRNA H19 and miR‐29b‐3p were predicted by bioinformatics analysis. C, The binding of lncRNA H19 and miR‐29b‐3p was confirmed by the dual‐luciferase reporter assay. *P < .05 compared with the miR‐NC group. D, Colocalization of lncRNA H19 and miR‐29b‐3p by FISH analysis; scale bar: 200 μm. E, The binding efficiency of lncRNA H19 and miR‐29b‐3p to Ago2 protein was detected by RIP. **P < .01 compared with the vector group. F, The relationship between lncRNA H19 and miR‐29b‐3p was tested by RNA pull‐down. *P < .05 compared with the Bio‐NC group. The data are shown as mean ± SD (n = 3)