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. 2021 Jan 13;129(1):017002. doi: 10.1289/EHP7310

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EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.

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Figure 2 is a flowchart comprising three steps. Step 1: A lag time leads to skin. Step 2: Skin with Absorption rate constant leads to volume of central compartment. Step 3: Volume of central compartment leads to first order elimination rate constant and with two rate constants leads to peripheral compartment. There is a two-way arrow between volume of central compartment and peripheral compartment. — Compartmental model used in the toxicokinetic analysis: lag time for skin penetration ( $T_{lag}$ , h), first order skin absorption constant ( $K_{a}$ , h-1), volume of central compartment (V, L), peripheral compartment (P) first order transfer rate constants ( $k_{12}$ and $k_{21}$ , $h^{- 1}$ ), and first order elimination rate constant (k, $h^{- 1}$ ).