Table 2.

Area under the urine excretion rate curve (${\text{AUC}}_{(0–40\mathrm{h})}$), lag time for dermal absorption and dermal absorption rate constant by FLG null and CNV genotype.

Chemical	Genotypea	${\text{AUC}}_{(0–40\mathrm{h})}$ (nmol, geometric mean; 95% CI)	$p$-Value (ANOVA)	Lag time (h, $\text{mean}\pm \text{SD}$)	$p$-Value (ANOVA)	Absorption rate constant (${\mathrm{h}}^{-1}$, $\text{mean}\pm \text{SD}$)	$p$-Value (ANOVA)
Pyrimethanil	FLG null	1,676; 1,253, 2,243	0.038b,c	$0.14\pm 0.02$	0.0001	$0.19\pm 0.04$	0.02
	FLG wt CNV20–22	1,421; 1,047, 1,927		$0.37\pm 0.06$		$0.20\pm 0.05$	—
	FLG wt CNV23–24	799; 494, 1,294		$0.66\pm 0.12$		$0.13\pm 0.03$	—
Pyrene	FLG null	28.4; 22.9, 35.1	0.195d	$0.91\pm 0.12$	0.011	$0.16\pm 0.05$	0.019
	FLG wt CNV20–22	27.2; 21.8, 34.0		$1.06\pm 0.16$		$0.14\pm 0.03$	—
	FLG wt CNV23–24	19.6; 13.8, 27.9		$1.41\pm 0.29$		$0.11\pm 0.03$	—
Oxybenzone	FLG null	1,161; 891, 1,510	0.165e	$0.07\pm 0.01$	0.000008	$0.23\pm 0.07$	0.0046
	FLG wt CNV20–22	1,061; 797, 1,409		$0.04\pm 0.009$		$0.22\pm 0.08$	—
	FLG wt CNV23–24	711; 459, 1,104		$0.23\pm 0.13$		$0.13\pm .04$	—

Note: $p$-Values for comparisons are between FLG null ($n=22$), wt CNV20–22 ($n\left[\text{oxybenzone}\right]=19$, $n\left[\text{pyrimethanil and pyrene}\right]=20$), and wt CNV23–24 ($n=8$). —, no data; ANOVA, analysis of variance; CI, confidence interval; CNV, copy number variants.

^aThree participants do not have information about CNV.

^bSignificant pairwise comparison between FLG null and wt CNV23–24: $P=0.011$, and between wt CNV20–22 and wt CNV23–24: $p=0.048$.

^c$R^2=0.13$.

^d$R^2=0.067$.

^e$R^2=0.075$.