How this fits in

Men in the UK are generally regarded as having a low uptake of prostate cancer screening, but the largest ever screening trial, the Cluster Randomised Trial of PSA [prostate-specific antigen] Testing for Prostate Cancer, was based in the UK. In this observational study, to the authors’ knowledge, the largest and most comprehensive assessment of opportunistic prostate cancer screening behaviours in England was performed in a cohort study of >2.8 million men. It was found that a sizeable proportion of men opt in to opportunistic PSA screening every year The results suggest that this ‘screening on demand’ may have significant implications. For example, nuanced interpretation of trials in UK men may be needed, and rates of opportunistic screening may contextualise observed trends in prostate cancer diagnosis and outcomes.