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[Preprint]. 2021 Jan 9:2021.01.09.426034. [Version 1] doi: 10.1101/2021.01.09.426034

Figure 1. Outcomes following treatment with different poly I:C preparations.

Figure 1.

C57BL/6J female adult mice were placed in an open field 2h 50min post-treatment and measures of locomotion (a) and rears (b) were accumulated over a 10min trial period. Intraperitoneal treatments were saline (n=5), 12mg/kg Amersham poly I:C (n=4) and 12mg/kg Sigma poly I:C (n=5). (c-e): Systemic expression of the pro-inflammatory cytokines IL-6 (c), TNFα (d) and IFNβ (e) were determined using ELISA in C57/BL6J female adult mice 3h post-treatment in the same animals. All data are represented as mean +/− SEM and were compared using one-way ANOVA, followed by Bonferroni post-hoc tests. In a & b *p<0.05 denotes significant differences from saline-treated animals while in c-e **p<0.01 and ***p<0.001 denote significant differences between the 2 poly I:C preparations. ND denotes not-detectable.