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[Preprint]. 2021 Jan 9:2021.01.09.426034. [Version 1] doi: 10.1101/2021.01.09.426034

Figure 3. Effects of increasing the dose of LMW poly I:C.

Figure 3.

a) C57BL/6J female adult mice were placed in an open field 2h 50m post-treatment and measures of locomotion (lower beam breaks) and rears (upper beam breaks) were accumulated over a 10m trial period. b) Systemic expression of the pro-inflammatory cytokines IL-6, IFNβ and TNFα were determined using ELISA. c) Transcription of the pro-inflammatory cytokines Il6, Ifnb and Tnfa in liver tissue were determined using real time PCR. Data represent mean +/− SEM for saline (n=4), 20mg/kg Amersham poly I:C (n=4), 40mg/kg Sigma poly I:C (n=5) and 80mg/kg Sigma poly I:C (n=5). All data were compared using one-way ANOVA, followed by Bonferroni post-hoc tests comparing differences between each treatment group. *p<0.05, **p<0.01 and ***p<0.001 denote significant differences between saline and the represented poly I:C preparation. $p<0.05, $$p<0.01 and $$$p<0.001 denote significant differences between 40mg/kg Sigma poly I:C and the represented poly I:C preparation. +p<0.05, ++p<0.01 and +++p<0.001 denote significant differences between 20mg/kg Amersham poly I:C and the represented poly I:C preparation.