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[Preprint]. 2021 Jan 8:rs.3.rs-106579. [Version 1] doi: 10.21203/rs.3.rs-106579/v1

Figure 3. Lipidome network in non-resolving trauma patients at 72h.

Figure 3.

(A) Correlation network among 412 lipids from 14 classes represented in the lipidomic dataset. Each dot indicates a lipid and is depicted in a circle if it belongs to one class. Highly correlated (Pearson coefficient > 0.7) lipids are represented by edges. Only inter-class correlations are shown. Relative levels are color coded for each lipid species between non-resolving and resolving trauma patients at 72h after admission.

(B) Synthesis pathways for the 14 lipid classes summarized from published literature. Colored by differential levels of each lipid class between non-resolving and resolving trauma patients at 72h admission. Abbreviations: ATGL, Adipose Triglyceride Lipase; DAGT, diacylglycerol acyltransferase; G3P, glycerol-3-phosphate; CDP-Eth, Cytidine diphosphate-Ethanolamine; CDP-Ch, Cytidine diphosphate-Choline, CDP-DAG, Cytidine diphosphate-diacylglycerol, EPT, Ethanolamine phosphotransferase; CPT, Choline phosphotransferase; IPT, inositol phosphatidyltransferase. PLA, phospholipase A; PEMT, Phosphatidylethanolamine N-methyltransferase; LCAT, cholesterol acyltransferase; SMS, Sphingomyelin Synthase; SMase, Sphingomyelin phosphodiesterase; DEGS, dihydroceramide desaturase.