Figure 3:

Separation process of S2 and S1 domain of Chain C with/without Nrp1; here shown in absence of Nrp1, top (1st. of 7 simulations shown) and for Nrp1: Spike model 7, bottom. (Color coding: S1 in green and S2 in purple; Nrp1 in orange) The displacement of S2 domain center of mass relative to initial position is given as distance d. The time interval between the structures is 2, 5, 7, 10, 16 ns or 2, 5, 6, 7 ns in the pulling simulation (1 nm/ns).