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(a) Separation process of S2 and S1 domain of Chain A, B and C with three Nrp1s binding to each unit of the Spike protein trimer. The displacement of the S2 domain relative to initial position is shown. (b) Pulling force versus displacement of S2 domain with three Nrp1 binding. Averaged over 2 simulations for model 1 (red) whereas the ACE2 data is taken from Fig. 4c.
