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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: J Immunol. 2020 Sep 21;205(9):2489–2498. doi: 10.4049/jimmunol.1901284

Figure 3. The ferroportin/hepcidin macrophage axis is altered in smokers and in subjects with COPD.

Figure 3.

(a) HAMP mRNA (non-smoker n = 5, smoker n = 6, COPD n = 9), (b) SLC40A1 mRNA (non-smoker n = 5, smoker n = 6, COPD n = 8) expression levels in lung-derived macrophages from lung tissue macrophages isolated from lung parenchyma. (c) HAMP mRNA (non-smoker n = 7, smoker n = 5, COPD n = 8) and (d) SLC40A1 mRNA (non-smoker n = 7, smoker n = 6, COPD n = 9) expression levels of monocyte derived macrophages generated from monocytes isolated from peripheral blood mononuclear cells stimulated with granulocyte-macrophage colony stimulating factor (2 ng/ml GM-CSF for 12 days). All data are mean ± s.e.m. *P < 0.05 by Kruskall-Wallis followed by Dunn’s post-hoc test.