Table 1a. Table 1a: Oncogenes in HGSOC.

GENE	CHR	FREQUENCY OF ALTERATION				FUNCTIONS		OUTCOME		REF
		REPORT(N)		TCGA (N=316)		IN VITRO	IN VIVO	REPORT	TCGA
		AMP	EXP (RNA/PTN)	AMP	EXP (RNA)
RAB25	1q22	54% (52)	88.7% (62)	6.9%	-	Cell proliferation, prevents apoptosis & anoikis	Ectopic expression induced tumors	↓ PFS & OS	NS	[84]
CXCR2	2q35	NA	69.2% (13)	0.3%	3.8%	Cell cycle progression & angiogenesis	Knockdown reduced tumor growth	↓ PFS & OS	NS	[85]
TMEM158	3q21.3	NA	84% (25)	1.58%	4.43%	Cell proliferation ,cell cycle progression, adhesion & invasion	Knockdown reduced tumor growth	NA	NS	[86]
RPL22L1	3q26.2	NA	NA	18.6%	3.4%	EMT, Invasion & metastasis	Ectopic expression induced tumors	NA	↑ OS	[87]
USP13	3q26.33	NA	NA	16.1%	6.32%	Cell proliferation & colony formation	Knockdown reduced tumor growth & metastatic nodules	↓ OS	NS	[88]
TRIM52	5q35.3	NA	90% (192)	1.26%	5.37%	Cell proliferation, migration, invasion & prevents apoptosis	Knockdown reduced tumor growth	NA	PFS	[89]
FABP4	8q21.13	NA	NA	1.2%	10%	Cell migration & invasion	Ectopic expression induced tumors & metastatic nodules	↓ PFS & OS	NS	[90]
YAP	11q22.1	NA	22.64% (106)	4.7%	4.4%	Cell proliferation, resistance, cell migration & anchorage-independent growth	Knockdown reduced tumor growth & metastatic nodules	↓ PFS	NS	[91]
URI1	19p12	9.4% (434)	34.9% (475)	17.4%	9.1%	Cell survival & cisplatin resistance	Knockdown reduced tumor growth	↓ PFS	OS	[92]
NOTCH3	19p13.12	NA	35.3% (44)	11.7%	4.1%	Cell proliferation, prevents apoptosis & anoikis	Knockdown reduced tumor growth & tumor nodules	NA	OS	[93]
ZNF217	20q13.2	59% (44)	NA	4.4%	1.5%	Proliferation & Metastasis	Ectopic expression induced tumors & metastasis	↓ PFS	NS	[94]
KLF8	Xp11.21	NA	76.3% (55)	0%		Transformation of Ovarian epithelial cells	Ectopic expression induced tumors	NA	-	[95]

The above mentioned genes are altered in ≥10% of patients with HGSOC