Table 4.

Pharmacokinetic parameters of macozinone and 1d in male ICR mice following oral or intravenous administration

Parameters	Units	Macozinone		1d
		PO	iv	PO	iv
t1/2β	h	1.68	0.86	1.74	1.84
Tmax	h	0.25	0.033	0.25	0.033
Cmax	ng/ml	251	1230	110	1335
AUC(0-t)	hang/ml	354	423	174	445
Vd	L/kg	–	5.64	–	11.3
Cl	ml/min/kg	–	75.8	–	71.2
F	%	16.7	–	7.8	–

^aThe doses of oral and intravenous administration were 10 and 2 mg/kg, respectively