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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Hypertension. 2020 Mar 30;75(5):1233–1241. doi: 10.1161/HYPERTENSIONAHA.120.14642

Figure 5. Accumulation of FOXO3a led to upregulation of cell senescence gene p53 and p16 in the aging kidney.

Figure 5.

(A) Expression of phosphorylated FOXO3a and total FOXO3a in mouse kidneys, ratio of t-FOXO3a to β-actin and ratio of p-FOXO3a to t-FOXO3a. (B) Expression of p53 and p21 in mouse kidneys and quantitation of p53 and p21 expression in mouse kidneys. (C) Expression of p16 and quantitation of p16 in mouse kidneys. N=4.. Data are expressed as the mean ± S.D. * p < 0.05, or ** p<0.01 by unpaired t-test and multiple groups by one-way analysis of variance.