Figure 2.

Correlation of CMTESv2 and disease duration as surrogate evidence of disease progression. The disease duration was calculated by subtracting the age of onset from the age at assessment at the baseline visit. The dashed line represents the linear regression coefficient (R²). 148 patients with a dominant pathogenic or likely pathogenic MFN2 variant had CMTESv2 data at their baseline visit; the correlation between CMTESv2 and disease duration is statistically significant (two-tailed Spearman’s ρ 0.44, P < 0.001).