Table 3.
Mean change and SRM of CMTESv2, CMTESv2-R and CMTPedS in AD-CMT2A and AR-CMT2A at 1- and 2-years follow-up
| Follow-up, years | n | Baseline | Change | P | SRM | |
|---|---|---|---|---|---|---|
| Autosomal dominant | ||||||
| CMTESv2 | 1 | 38 | 10.66 ± 5.94 | 0.84 ± 2.42 | 0.039 | 0.35 |
| CMTESv2R | 1 | 38 | 14.53 ± 6.96 | 0.63 ± 3.19 | 0.230 | 0.20 |
| CMTESv2 | 2 | 34 | 9.47 ± 6.26 | 0.97 ± 1.77 | 0.003 | 0.55 |
| CMTESv2-R | 2 | 34 | 13.00 ± 7.68 | 1.21 ± 2.52 | 0.009 | 0.48 |
| Autosomal recessive | ||||||
| CMTESv2 | 1 | 6 | 12.33 ± 6.65 | 0.17 ± 3.06 | 0.900 | 0.05 |
| CMTESv2-R | 1 | 6 | 17.00 ± 7.21 | −0.33 ± 2.73 | 0.777 | −0.12 |
| CMTESv2 | 2 | 4 | 10.25 ± 7.23 | 0.25 ± 1.26 | 0.718 | 0.20 |
| CMTESv2-R | 2 | 4 | 14.75 ± 7.63 | 0 ± 1.41 | 1.000 | 0 |
| CMTESv2 | 4 | 5 | 13.40 ± 6.66 | 1.80 ± 3.11 | 0.266 | 0.58 |
| CMTESv2R | 4 | 5 | 17.60 ± 7.23 | 1.40 ± 3.91 | 0.468 | 0.36 |
| Autosomal dominant and autosomal recessive | ||||||
| CMTPedS | 1 | 17 | 25.41 ± 8.01 | 2.24 ± 3.09 | 0.009 | 0.72 |
| CMTPedS | 2 | 7 | 28.86 ± 7.82 | 4.00 ± 3.79 | 0.031 | 1.06 |
The CMTESv2 changed significantly over 1 and 2 years in patients with AD-CMT2A, whereas the CMTESv2-R changed significantly over 2 years. The CMTPedS (all cases grouped) changed significantly both over 1 and 2 years. There was no significant change in cases with AR-CMT2A over 1 and 2 years. Mean changes that are statistically significance have their P-values and SRMs highlighted in bold. Data shown represent mean ± SD.