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. 2020 Nov 9;143(12):3699–3716. doi: 10.1093/brain/awaa320

Figure 7.

Figure 7

Elevated O-GlcNAcylation mitigates impairments in dopamine transmission and motor learning caused by α-synuclein. (A) Schematic illustration depicting the injection of α-synuclein AAV virus (A53T) into SNc (left hemisphere). (B and C) Quantification and summary statistics of dopamine release evoked by one pulse or five pulse stimulation in DLS from DAT-Cre;Ai32;Oga+/+ and DAT-Cre;Ai32;Ogafl/fl mice injected with α-synuclein (A53T) virus. (D) Examples of movement path in the open field test in DAT-Cre;Oga+/+ and DAT-Cre;Ogafl/fl mice injected with either PBS or α-synuclein (A53T) virus. (E and F) Locomotive behaviour by total distance travelled and total moving time in the open field test. (G and H) Summary statistics for rearing behaviour in the cylinder test. (I) Performances in the wire-hanging test. (J and K) Motor learning in the rotarod test during training days and test days. Blue bar indicates 450 nm light stimulation. Data were analysed by repeated measures two-way ANOVA followed by Sidak’s post hoc test (C, E, I and J) and one-way ANOVA followed by Sidak’s post hoc test (E–H and K). Data are represented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.