FIGURE 1.

Trends of BETA-2 in patients after TPIAT due to chronic pancreatitis and intractable pain. A, Trends of BETA-2 in group 1 (n = 9) in patients with long-term insulin independence. Patients were supported initially with exogenous insulin (dotted line) to support islet function and optimize conditions for islet engraftment. Afterward, insulin was successfully weaned off maintaining optimal glucose control (continuous line represents insulin independence). In insulin-independent patients, the BETA-2 scores remain above 15 (dashed line) and thus reflect stable islet graft function. Nevertheless, the scores are noted to fluctuate. B, Trends of BETA-2 in group 2 (n = 4) in patients with partial islet graft function and good functional outcomes based on Igls classification.^2,4 Patients required minimal insulin support once a day with long-acting insulin or only small doses during their meals. In those patients, BETA-2 scores also remained stable and fluctuated in a range above 10 (dashed line), reflecting stable islet graft function. The legend shows decreasing doses of insulin supplementation for individual patients corresponding to lines with different colors.