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. 2021 Jan 13;7(3):eabd4235. doi: 10.1126/sciadv.abd4235

Fig. 1. Synergistic cytokine responses from BM-APCs induced by PLPs with MPLA and CpG depend on CpG adjuvant density.

Fig. 1

(A) Schematic of particle formulations for the co-delivery of MPLA and CpG. (B to F) Murine GM-CSF–differentiated murine BM-APCs (300,000 cells per well) were treated with formulations of varying size and CpG ligand density. IFN-β, IL-12p70, IL-6, TNF-α, and IL-10 in cell supernatants 24 hours after treatment. Each data point represents an independently treated well (n = 5). Center lines designate the mean value, and error bars represent SD. ***P < 0.001 and ****P < 0.0001; NS, not significant; one-way analysis of variance (ANOVA) with Tukey’s multiple comparison test.