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. 2021 Jan 13;7(3):eabd4235. doi: 10.1126/sciadv.abd4235

Fig. 2. Knockdown of the adaptor protein TRIF ablates synergy from PLPs with MPLA and CpG in BM-APCs.

Fig. 2

(A) Schematic showing early signaling through the adaptor proteins MyD88 and TRIF following activation of TLR4 and TLR9. (B) IFN-β production from ΒΜDCs derived from WT, MyD88−/−, and TRIF−/− mice after PLP treatment. (C) IL-12p70 production from BM-APCs derived from WT, MyD88−/−, and TRIF−/− mice after PLP treatment. Each data point represents an independently treated well (n = 5 to 6). Center lines designate the mean value, and error bars represent SD. *P < 0.05 and ****P < 0.0001; NS, not significant; one-way ANOVA with Tukey’s multiple comparison test.