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. 2021 Jan 13;7(3):eaaz8836. doi: 10.1126/sciadv.aaz8836

Fig. 4. EGR1 interacts with the NuRD chromatin remodeler complex.

Fig. 4

(A) Mass spectrometry data in both HL-60 and HEK293T cells show that EGR1 interacts with all NuRD subunits. (B) ChIP-seq data for NuRD’s catalytic subunit CHD4 support recruitment of NuRD at EGR1-binding sites at the repressed inflammatory enhancers. (C) Plot of Pearson correlation between CHD4 and EGR1 ChIP-seq read coverage at the 5479 EGR1-gaining regions in day 5 macrophages. A Pearson’s r of 0.96 indicates a high correlation of CHD4 and EGR1 binding at these sites (P = 2.2 × 10−16).