. 2021 Jan 12;5(2):e523. doi: 10.1097/HS9.0000000000000523

Table 3.

Treatment of Stage III/IV/Relapsed Disease.

Treatment	Stage	No. Patients (n)	Response (%)	PFS (%)	OS (%)	Grade 3/4 Toxicity (%)	References
SMILE	III/IV, refractory, relapsed	38	ORR 79	1-y 53	1-y 55	Neutropenia 100	Yamaguchi et al³¹
			CR 45			Infection/febrile neutropenia 61
			CR 45			TRM 0
SMILE	III/IV, refractory, relapsed	47	ORR III/IV 81	4-y R/R 68,2	5-y R/R 52,3	Neutropenia 67	Kwong et al³⁸
			ORR R/R 75	St III/IV NA	St III/IV NA	Infection/febrile neutropenia 31
			ORR R/R 75	St III/IV NA	St III/IV NA	TRM 6
DDGP	III/IV, refractory, relapsed	80	ORR 90	3-y 57	5-y 74	Neutropenia 71	Li et al⁴⁴
						Infection/febrile neutropenia NA
						TRM 0
P-GEMOX	III/IV, refractory, relapsed	35	ORR 94	2-y 39	2-y 65	Neutropenia 40	Wang et al⁴²
			CR 26			Infection/febrile neutropenia NA
			CR 26			TRM 0
GDP	III/IV, refractory, relapsed	41	ORR 83	1-y 55	1-y 73	Neutropenia 34	Wang et al⁴³
			CR 42			Infection/febrile neutropenia NA
			CR 42			TRM 0

CR = complete remission; DDGP = PEG-asparaginase, gemcitabine, cisplatin, and dexamethasone; GDP = gemcitabine, dexamethasone, and cisplatin; NA = not available; ORR = overall response rate; OS = overall survival; PEG = pegylated; PFS = progression-free survival; P-GEMOX = PEG-asparaginase, gemcitabine, and oxaliplatin; SMILE = dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide; TRM = treatment-related mortality.