Figure 14. SOCE role in maintaining submucosal interstitial cells of Cajal (ICC-SM) Ca²⁺ transients.

(A) Representative Heat-map image of an ICC-SM network showing total active Ca²⁺ PTCLs under control conditions and in the presence of GSK-7975A (10 μM, for 20 min) B. C and D Ca²⁺-firing sites are color coded and plotted in occurrence maps showing the effect of the SOCE channel antagonist, GSK-7975A (100 μM), on ICC-SM Ca²⁺ transients. Traces of PTCL area (E; blue) and PTCL count (E; green) under control conditions and in the presence of GSK-7975A, PTCL area (F; blue) and PTCL count (F; green). Summary graphs of Ca²⁺ PTCL activity in ICC-SM in the presence of GSK-7975A are shown in G (PTCL area), (H) (PTCL count), (I) the number of PTCL active sites, and J (PTCL duration; n = 7). Significance determined using unpaired t-test, **** = p<0.0001. All data graphed as mean ± SEM.