Table 2. Open reading frames (ORFs) identified by fixation index (FST) as being significantly more similar in strains transmitted prenatally.
LD: Found to contain one of 33 hotspots of genetic linkage disequilibrium (Lassalle et al., 2016).
| ORF | LD | Function |
|---|---|---|
| UL10 | Y | Putative membrane glycoprotein. Immunosuppressive, Impairs T cell function (Bruno et al., 2016) |
| UL11 | Y | Membrane glycoprotein. Modulates T cell signalling/function (Gabaev et al., 2014; Arcangeletti et al., 2015) |
| UL13 | Unknown function | |
| UL4 | Y | Putative membrane glycoprotein (Van Damme and Van Loock, 2014) |
| UL5 | Putative membrane glycoprotein (Van Damme and Van Loock, 2014) | |
| UL6 | Y | Putative membrane glycoprotein (Van Damme and Van Loock, 2014) |
| UL7 | Y | Membrane glycoprotein. Modulates chemo- and/or cytokine-signalling function (Pérez-Carmona et al., 2018) |
| UL8 | Y | Transmembrane glycoprotein. Inhibits proinflammatory cytokines (Pérez-Carmona et al., 2018) |
| US26 | Unknown function | |
| US27 | Y | Membrane glycoprotein. Activates CXCR4 signalling to increase human cytomegalovirus replication (Frank et al., 2019) |
| UL150A | Fibroblast and epithelial cell entry (Houldcroft et al., 2016) | |
| UL2 | Putative membrane glycoprotein (Van Damme and Van Loock, 2014) | |
| RL11 | Y | Membrane glycoprotein. Binds IgG Fc domain involved in immune regulation (Van Damme and Van Loock, 2014) |
| UL147 | α-Chemokine homologue (Katoh and Standley, 2013; Paradis and Schliep, 2019) | |
| UL40 | Control of NK recognition (Heatley et al., 2013) | |
| RL13 | Y | Glycoprotein, repression of replication, binds IgG domain immune regulation (Stanton et al., 2010; Cortese et al., 2012) |
| RL10 | Membrane glycoprotein | |
| UL57 | Ss DNA binding protein (Van Damme and Van Loock, 2014) | |
| UL50 | Nuclear Egress complex. Reduces interferon-mediated antiviral effect (DeRussy et al., 2016) |