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. 2021 Jan 6;2021:5318369. doi: 10.1155/2021/5318369

Figure 1.

Figure 1

Increased expression of SNHG14 in LPS-induced HK-2 cells is due to the activation of the TLR4/NF-κB pathway. (a) Expression level of SNHG14 in LPS-treated HK-2 cells. (b) Predicted binding site of NF-κB in the SHNG14 promoter. (c) Activation of the TLR4/NF-κB pathway in LPS-induced HK-2 cells. (d) ChIP assay showed NF-κB bound to the SNHG14 promoter. (e) Luciferase assays showed that overexpressing NF-κB p65 increased the activity of luciferase reporter containing a wild-type SNHG14 promoter. (f) SNHG14 levels in LPS-induced HK-2 cells transfected with NF-κB p65 overexpression plasmids or shRNAs. Data were shown as mean ± SD, ∗P < 0.05.