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. 2021 Jan 1;11(6):2742–2754. doi: 10.7150/thno.51183

Figure 5.

Figure 5

12/15LOX deletion modulates MI-induced cardiorenal pro-resolving and pro-inflammatory response in AHF and CHF. Kidney and LVI mRNA expression of (A, D) proresolving marker-MRC-1 (B, E) proinflammatory marker-TNF-α (C, F) Monocyte/macrophage- and neutrophil-mediated inflammatory response marker-TREM-1 at acute (post-MI d1) and chronic (post-MI d56) phase in WT and 12/15LOX-/- mice. Values are represented as mean ± SEM; n = 5 *p < 0.05 vs WT. Analysis of variance (ANOVA), followed by Newman-Keuls post-hoc test, was used for multiple comparisons. (G) TUNEL staining at post-MI d56 in kidney representing decrease in apoptotic cells (TUNEL positive cell: green) in 12/15LOX-/- mice compared with WT mice (magnification 40X, scale = 20µm). Images are representative of 5-8 field/slide; n = 4 slide/group.