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Assessment of islet accumulation of compounds by LC-MS/MS
(A) Experimental workflow includes incubation of isolated islets or exocrine pancreas with chelator, followed by quantification by LC-MS/MS.
(B) Representative raw data for standard concentrations of TSQ.
(C) Representative calibration curve for TSQ standards shown in (B).
(D) Representative peaks and quantification for islets treated with TSQ, without and with TPEN.
