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Assessment of β cell-selective replication
(A) Experimental workflow involves islet isolation, dispersal to single cells by trypsinization, compound treatment and incubation, fixing and antibody staining, and quantification of replication by ArrayScan methodology.
(B) Representative results for a control non-chelating and chelating replication compound, with β cell replication signified by yellow arrows, and non-β cell replication signified by white arrows.
