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. 2021 Jan 7;40:101859. doi: 10.1016/j.redox.2021.101859

Fig. 6.

Fig. 6

FGF10 knockdown aggravates hepatocellular apoptosis during the injury phase and impairs hepatocyte proliferation during the recovery phase of liver IRI. Mice were subjected to 90 min of partial liver warm ischemia, followed by 6 h or 24 h of reperfusion. (A) Representative TUNEL staining of liver sections from mice treated with AAV-sh-Con/AAV-sh-Fgf10 after sham/IRI (magnification × 100). (B) Protein expression levels of Bax, Bcl-2, and c-CAS-3 in the livers of mice treated with AAV-sh-Con/AAV-sh-Fgf10 after sham/IRI. (C) Representative Ki-67 IHC staining of liver sections from mice treated with AAV-sh-Con/AAV-sh-Fgf10 after sham/IRI (magnification × 400). (D) Protein expression levels of PCNA, cyclin D1, and cyclin E1 in the livers of mice treated with AAV-sh-Con/AAV-sh-Fgf10 after sham/IRI. For (B) and (D), GAPDH was served as the loading control. All data are presented as mean ± SD, n = 4–6 mice/group, #P < 0.05.