Fig. 8.

FGF10 knockdown aggravates inflammatory responses during hepatic IRI. Mice were subjected to 90 min of partial liver warm ischemia, followed by 6 h of reperfusion. (A) Representative CD68 and MPO IHC staining of liver sections from mice treated with AAV-sh-Con/AAV-sh-Fgf10 after sham/IRI (magnification × 100). (B) Protein expression levels of NF-κB signaling in the livers of mice treated with AAV-sh-Con/AAV-sh-Fgf10 after sham/IRI (GAPDH was served as the loading control). (C) The mRNA levels of pro-inflammatory factors (Tnf-α, Il-1β, Il-6, Ccl2, and Cxcl2) in the livers of mice treated with AAV-sh-Con/AAV-sh-Fgf10 after sham/IRI. All data are presented as mean ± SD, n = 4–6 mice/group, #P < 0.05.