Table 3.

Association between levels of MR-proANP and incident atrial fibrillation or cardiovascular disease

	n	Model 1		Model 2		Model 3
		Odds ratio per SD [95% CI]	p value	Odds ratio per SD [95% CI]	P value	Odds ratio per SD [95% CI]	p value
Estimates for incident atrial fibrillation
MR-proANP	3386	3.31 [2.31; 4.81]	< 0.0001	3.19 [2.22; 4.65]	< 0.0001	2.82 [1.86; 4.35]	< 0.0001
Estimates for incident cardiovascular disease (comprising atrial fibrillation, coronary artery disease, myocardial infarction, heart failure, or stroke)
MR-proANP	3015	1.33 [1.04; 1.71]	0.025	1.33 [1.03; 1.71]	0.026	1.49 [1.13; 1.96]	0.0046

Statistically significant p values (i.e. < 0.05) are given in bold font

Odds ratios and 95% confidence intervals are derived from a logistic regression model modeling for incident atrial fibrillation or cardiovascular disease (dependent variables) per 1-standard deviation increase in MR-proANP levels (independent variable). There were 43 incident cases of atrial fibrillation and 103 incident cases of cardiovascular disease at follow-up. n denotes model 3

Model 1 was adjusted for sex (categorical) and age (continuous)

Model 2 was additionally adjusted for socioeconomic status (continuous), length of time at current residence (continuous), and night shift work (categorical)

Model 3 was additionally adjusted for diabetes mellitus, arterial hypertension, smoking, obesity, dyslipidemia, family history of myocardial infarction or stroke, and medication use (diabetic drugs, antithrombotic agents, antihypertensives, diuretics, beta-blockers, calcium channel blocker, agents acting on the renin–angiotensin–aldosterone system, and lipid modifying agents) (all categorical)