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. 2021 Jan 13;11:1185. doi: 10.1038/s41598-020-80487-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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PA traces with signal waveform examples. (a) Human blood containing B1610 melanoma cells, (b) human blood containing melanoma cell phantoms, (c) hemoglobin solution containing melanoma cell phantoms, and (d) RBC phantoms’ suspension containing melanoma cell phantoms. Laser pulse energy, 100 µJ. (e) Mouse femoral vessel containing B16F10 in vivo. The insets show the examples of single waveforms.