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. 2021 Jan 13;11:1101. doi: 10.1038/s41598-020-79651-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Generation of photoreceptors. (Ai-ii) Widefield images of plated photoreceptors at D168 (black arrow), obtained from dissociated organoids, show outgrowth that is morphologically different to plated ganglion cells (Shown in Fig. 6a) (Scale bar = 200 µm). (B) Quantitative RNA sequencing data of common photoreceptor progenitor markers CRX and RCVRN showed increasing expression after day 63, while the mature cone and rod markers ARR3, OPN1SW and NRL, RHO also increased over time, although not as dramatically. (Ci-iii) Expression of photoreceptor progenitor markers was seen with IHC staining of RCVRN (in red) with the general neuronal marker β-III Tubulin (in green). (Di-iii) More mature photoreceptors were stained using anti-rhodopsin antibody ROD (in red).