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. 2021 Jan 13;11:1203. doi: 10.1038/s41598-020-80862-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Higher magnification (63 ×) Confocal images of yellow boxed area shown in Fig. 1H. A–D: showing MBD-MD-231 tumor, tumor edge and peritumor area. A, tumor cells (td-Tomato, red); INPs (Anti PEG, green); Endothelial Marker (Anti-CD31, violet), D, all four colors merged with nuclei stained with DAPI, blue. Highest INP staining intensity colocalized with CD31 at the tumor edge and peritumor region compared to the tumor center. Arrows: Groups of tumor cells with grape cluster appearance. Irregularly shaped spaces (ISS) delineated by endothelial stains (asterisks and diamonds). Diamonds: Spaces formed are contributed by tumor cells only Asterisks: Spaces formed are contributed by both tumor and non-tumor cells.