Table 1.
Patients demographics and clinical characteristics.
| Characteristic | Control (n = 89) | SIRS (n = 75) | Sepsis (n = 107) | p# |
|---|---|---|---|---|
| Age (years), mean ± SE | 51.9 ± 1.5 | 49.15 ± 1.9 | 54.9 ± 1.6 | 0.076 |
| Sex (Female/Male), (%) | 39/50 (44/56) | 26/49 (35/65) | 44/63 (41/59) | 0.478 |
| ICU LOS (days), mean ± SE | 25 ± 4.71 | 24 ± 2.67 | 0.863 | |
| Mortality ICU, n (%) | 9 (12) | 42 (38)† | 0.001 | |
| APACHE score, mean ± SE | 15 ± 0.73 | 22.4 ± 0.79† | 0.001 | |
| SOFA score, mean ± SE | 8.3 ± 0.3 | 10 ± 0.3† | 0.001 | |
| SAPS score, mean ± SE | 48.8 ± 1.5 | 71.5 ± 1.7† | 0.001 | |
| WBC × 103 (cells/μL), median (IQR) | 12.6 (9.5–16.7) | 13.9 (8.6–20) | 0.232 | |
| Lactate (mg/dl), median (IQR) | 4.3 (2–12.5) | 4.7 (1.95–23) | 0.575 | |
| CRP (mg/dl), median (IQR) | 9.5 (4.2–28.5) | 25.6 (13–89)† | 0.001 | |
| Procalcitonin (ng/ml), median (IQR) | 0.77 (0.44–1.82) | 5 (1.14–28.8))† | 0.011 | |
| IL-6 (pg/ml), median (IQR) | 3.5 (1.25–14.8)** | 77 (19.5–157)* | 86 (27.6–391) | 0.001 |
| IL-10 (ng/ml), median (IQR) | 3.7 (0.5–11.3)** | 10.2 (0.01–23.2)* | 16.7 (5.3–64.7)† | 0.001 |
| IL-8 (pg/ml), mean ± SE | 82.7 ± 14.2 | 84.3 ± 27.5 | 139 ± 24.4 | 0.109 |
#Differences among groups (ANOVA, Kruskal–Wallis, x2 test, as appropriate): Post hoc differences: *control-SIRS, **control-sepsis, †SIRS-sepsis.
SIRS systematic inflammatory response syndrome, IQR interquartile ratio, ICU intensive care unit, LOS length of stay, WBC white blood cells, CRP C-reacting protein, IL Interleukin.