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. 2021 Jan 13;11:1120. doi: 10.1038/s41598-020-80889-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Activated NG2⁺ pericytes in the striatum of TG mice. Confocal images showing NG2⁺ pericyte coverage (grey) of PDCLX⁺ vessels (red) in WT and TG mice and quantification of NG2⁺ pericyte density at (a) age of 3 months (n = 3 WT, 3 TG); (b) age of 8 months (n = 4 WT, 3 TG); and (c) age of 13 months (n = 4 WT, 4 TG). Confocal images showing NG2⁺ pericyte coverage (grey) of PDCLX⁺ vessels with α-syn-GFP in TG mice at age of 3 (d), 8 (e) and 13 (f) months. Two-tailed student’s t-test: *p-value < 0.05, ***p-value < 0.001. Scale bar: large image (a–f) 50 μm; image box (a–f) 20 μm. PDCLX = Podocalyxin, NG2 = Neuron-glial antigen 2, α-syn-GFP = alpha-synuclein green fluorescent protein.