Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 13;11:1234. doi: 10.1038/s41598-020-79663-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

InCeT-TLZ induces DNA damage and cell death in BRCA1-deficient tumor cells. (A) BRCA-deficient cancer cells (W780 and W0069) were treated with 2 or 4 mm InCeT-TLZ for 48 h. Biomarkers of DNA damage (γH2AX), cell death (cleaved (c)-caspase 3 and cleaved-PARP) and cell cycle arrest (cyclin D1) were detected by western blotting. W780 (B) and W0069 (C) were treated with a 1 mm empty spacer or InCeT-TLZ for 5 days. Cell viability was detected using the MTT assay. Results were normalized to the DMSO control. Data was shown as mean ± SD. ***p < 0.001 vs. DMSO control.