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. 2021 Jan 13;11:865. doi: 10.1038/s41598-020-79608-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Assessment of the prognostic potential of low and high (median) (A) PRO-C3 (formation of collagen type III), (B) PRO-C6 (formation of collagen type VI), (C) C6M (degradation of collagen type VIα1) and (D) C6Mα3 (degradation of collagen type VIα3) serum levels by Kaplan Meier plots. Cox proportional-hazards regression was used to calculate the hazard ratios (HR) with 95% Cl and p-values. A p < 0.05 was considered significant.