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. 2021 Jan 13;11:865. doi: 10.1038/s41598-020-79608-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Assessment of the prognostic potential of combining the different biomarkers by Kaplan Meier plots. (A) LL; low C6M and low C6Mα3, LH or HL; low C6M and high C6Mα3 or high C6M and low C6Mα3, HH; high C6M and high C6Mα3. (B) LL; low PRO-C3 and low PRO-C6, LH or HL; low PRO-C3 and high PRO-C6 or high PRO-C3 and low PRO-C6, HH; high PRO-C6 and high PRO-C6. (C) LL; low PRO-C6 and low C6Mα3, LH or HL; low PRO-C6 and high C6Mα3 or high PRO-C6 and low C6Mα3, HH; high PRO-C6 and high C6Mα3. (D) LLLL; low PRO-3, PRO-C6, C6M and C6Mα3, L/H*; at least one low or high PRO-C3, PRO-C6, C6M or C6Mα3, HHHH; high PRO-C3, PRO-C6, C6M and C6Mα3. Univariate Cox proportional-hazards regression was used to calculate the hazard ratios (HR) with 95% Cl and p-values. A p < 0.05 was considered significant.