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. 2021 Jan 13;11:1107. doi: 10.1038/s41598-020-80145-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Meta-analysis forest plots showing the effect size (x-axis) of exemplar gene-SNP pairs for each treatment condition (y-axis; M LPS: expression data in males in the LPS-treated samples; M Veh: expression data in males in the untreated controls; F LPS: expression data in females in the LPS-treated samples; F Veh: expression data in females in the untreated controls). Black boxes show the mean effect size; and the size of the box is proportional to the inverse of the standard error (larger boxes indicate a smaller standard error). The gray lines show the 95% confidence intervals. All eQTLs shown are significant in at least one condition at an lfsr < 0.05. (A) Example of an eQTL shared across all conditions. HLA-DQA2, Human leukocyte antigen DQ alpha 2. (B) Example of a sex-specific eQTL (males), NOG, Noggin. (C) Example of a treatment-specific eQTL (vehicle only), KIAA1324, estrogen-induced gene 121 protein. (D) Example of a treatment-specific eQTL (LPS only). IL36RN, interleukin 36 receptor antagonist. (E) Example of a treatment specific and sex specific eQTL (Female LPS only), NOXA1, NADPH oxidase activator 1. (F) Example of a treatment specific and sex specific eQTL (Male LPS only), IL1R1, interleukin 1 receptor type 1.