Table 1.

Number of differentially expressed (DE) genes (FDR < 0.05) in response to LPS on the autosomes and the X chromosome.

Category of genes	Autosomal	X-linked
Male-specific DE	632	23
Female-specific DE	585	31
Sex-specific	1217	54
DE in both sexes (FDR < 0.05)	8549	237
DE in both sexes (0.05 > FDR > 0.20)	1036	30
Neither DE (FDR > 0.20)	1673	72
Not specific	11,258	339
Sex-specific	1217	54
Not specific	11,258	339
Total	12,475	393

DE genes considered sex-specific were significant at FDR < 0.05 in the primary sex and not significant at FDR < 0.20 in the opposite sex. There was an enrichment of sex-specific responses to LPS among X-linked genes (54/393, 13.7%) compared to autosomal genes (1217/12,475, 9.8%) (Fisher’s Exact Test P = 0.01).