Table 2.

The log fold change responses of HLA genes expressed in PBLs to LPS treatment in the combined (n = 112), female (n = 66), and male (n = 46) samples.

Gene	Log Fold Change (Combined Sample)	Log Fold Change (Females)	Log Fold Change (Males)	FDR adj. P-value (response test in combined sample)	FDR adj. P-value (response test in females only)	FDR adj. P-value (response test in males only)	FDR adj. P-value (sex by treatment interaction test)
HLA-F	0.551	0.450	0.695	1.81 × 10–16	6.25 × 10–8	3.72 × 10–9	0.093
HLA-A	0.504	0.314	0.778	1.94 × 10–11	0.003	9.25 × 10–4	0.008
HLA-E	0.051	− 0.005	0.132	0.083	0.935	0.265	0.105
HLA-C	0.052	− 0.030	0.171	0.203	0.579	0.234	0.091
HLA-B	0.360	0.239	0.534	8.23 × 10–11	0.017	0.004	0.024
HLA-DRA	0.458	0.335	0.634	2.25 × 10–9	3.21 × 10–4	2.91 × 10–6	0.135
HLA-DRB1	− 0.519	− 0.768	− 0.160	1.61 × 10–7	0.001	0.062	0.014
HLA-DQA1	0.036	− 0.237	0.429	0.706	0.639	0.611	0.007
HLA-DQB1	− 0.001	− 0.322	0.463	0.995	0.353	0.994	0.023
HLA-DQA2	− 0.261	− 0.397	− 0.065	0.105	0.062	0.808	0.528
HLA-DOB	0.767	0.700	0.863	7.66 × 10–12	4.84 × 10–7	6.43 × 10–6	0.608
HLA-DMB	− 0.839	− 1.006	− 0.599	7.55 × 10–18	1.63 × 10–12	4.48 × 10–6	0.042
HLA-DMA	− 0.806	− 0.976	− 0.563	2.29 × 10–20	7.32 × 10–14	3.31 × 10–7	0.009
HLA-DOA	− 0.254	− 0.164	− 0.384	0.001	0.051	0.014	0.371
HLA-DPB1	− 0.686	− 0.765	− 0.573	4.54 × 10–17	0.107	0.859	0.304

Also presented are FDR-adjusted p-values for four tests: (1) test of significant response in the combined sample, (2) test of significant response in females, (3) test of significant response in males, and (4) test for sex by treatment interactions in the combined sample. Genes are presented in order from the telomeric to the centromeric end of the short arm of chromosome 6. Significant FDR-adjusted p-values < 0.05 are denoted with italics text.