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. 2021 Jan 13;11:1193. doi: 10.1038/s41598-020-80948-0

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Boxplot of baseline corrected median chromosome X log₂ R ratio (LRR) at age of sample collection for 196,219 male UK Biobank participants. Distribution of baseline corrected median LRR is plotted by 1-year age groups. Male baseline corrected LRR values are centered around 0. Instances where baseline corrected median LRR ≥ |0.15| (blue lines) indicate evidence for chromosome X mosaicism. Participants with LRR ≥ 0.4 (green line) are constitutional XXY (Klinefelter syndrome).