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Fc-FGF21 S1 and S3 has improved anti-diabetic effects than Fc-FGF21 (RA) in type 2 diabetic ob/ob mice. Drugs (20 nmol/kg) were given via single subcutaneous injection (n=8) and treated for the indicated time. Random blood glucose was measured (a); and glucose AUC were calculated (b). Data are presented as mean +/- standard deviation, and Student's t-test was used for statistical analysis. *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001 (vs. control).
