Fig. 6.

Profile of lipoproteins and liver function markers in ob/ob mice with HFD-induced NASH. Mice were treated with the indicated single or dual target proteins by subcutaneous injection twice a week (day 0 and day 3) for 4 consecutive weeks (n=8). At the end of the treatment on day 29 multiple measurements were done. (a) blood lipid, TC. (b) LDL levels. (c) Blood ALT. (d) AST levels. (e) Liver weight. (f) Liver TG. (g) liver TC levels. Data are shown as mean +/- standard deviation, Student's t-test was used for statistical analysis. *P<0.05; **P<0.01; ***P<0.001 (vs. control). TC, total cholesterol; LDL, low-density lipoprotein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; Liver TG, Liver triglyceride; Liver TC, Liver total cholesterol.