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Summary of the kinetic and affinity constants (KD) for the interaction between FGF21 mutants and β-Klotho using streptavidin (SA) biosensors.
| Sample ID | KD (M) |
|---|---|
| Fc-FGF21 (RA) | 7.67E-10 |
| Fc-FGF21 (S167H,R175L) S1 | 3.16E-10 |
| Fc-FGF21 (S167H) S3 | 5.90E-10 |
| GLP-1-Fc-FGF21 (S167H,R175L) D1 | 9.24E-11 |
| GLP-1-Fc-FGF21 (S167H) D3 | 2.40E-10 |
