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The expression of HIF-1α in NSCLC tissues before receiving EGFR-TKIs treatment and after gaining EGFR-TKIs acquired resistance for patients receiving a second biopsy.
| Group | HIF-1α expression score | Median (P25th, P75th) | P value |
|---|---|---|---|
| Before EGFR-TKIs treatment | After EGFR-TKIs acquired resistance | ||
| Second biopsy group (n = 41) | 6 (3, 8.5) | 8 (6, 10.5) | 0.000 |
| T790M mutation group (n = 20) | 5.5 (2.25, 8.5) | 7.5 (5.25, 9.75) | 0.012 |
| Without T790M mutation (n = 21) | 7 (3, 8.5) | 9 (8, 11) | 0.001 |
