Table 7.
Cox regression analysis of clinical characteristics as influencing factors of EGFR-TKIs acquired resistance occurring for 103 cases receiving EGFR-TKIs treatment.
| Clinical characteristics | HR | 95% CI | P value |
|---|---|---|---|
| Age | 0.925 | 0.591–1.447 | 0.731 |
| Gender | 0.653 | 0.351–1.215 | 0.178 |
| Smoking | 0.649 | 0.348–1.207 | 0.172 |
| Clinical stage | 1.016 | 0.658–1.569 | 0.944 |
| EGFR sensitive mutation type | 0.874 | 0.592–1.291 | 0.498 |
| EGFR-TKI type | 0.722 | 0.570–0.915 | 0.007 |
| HIF-1α level | 0.045 | 0.021–0.099 | 0.000 |
HR hazard ratio, CI confidence interval.